WHY "THE BIRTH OF VENUS"?
Sandro Botticelli‘s painting from 1486 is one of the most wonderful artistic presentations of an evolutionary process ‚The birth of Venus'.
He painted an evolutionary process by indicating where Venus comes from, either ‚out‘ or at least from the water site. Due to the upcoming transfer from water to land, she has to be protected in her novel environment. Winds and the flow of the water are the driving forces facilitating for finally going on shore.
Where are the parallels to anakoinosis in cancer?
The starting point for each tumor therapy is the histological specimen, an informative ‚painting‘. From a histologic ‘painting’, we can hardly conclude which are the current evolutionary driving forces. The specimen represents a snapshot, which may be supplemented by further immune-histological, molecular-genetic or genetic information.
Thus, we can gather situational data about what we intend to unidirectional shut-off or eliminate for achieving cytostasis or cytotoxicity, but get insufficient information about therapeutically accessible complex communicative processes.
Anakoinosis, however, aims at modifying multi-level communicatively developing evolutionary processes, here the tumor disease. Anakoinosis therapeutically considers the tumor phenotype as a design space, with the intention for re-establishing differentiation and apoptosis competence, just via an evolutionary process.
In contrast to the routinely missing ‘evolution-adjusted tumor pathophysiology’ as prerequisite for designing pro-anakoinotic therapeutic interventions, Boticelli’s ‘Birth’ artistically delicately dovetails the ‘driving forces’ of Venus’ evolution under the respective bright environmental conditions. Moreover, the painting figures out both, the beauty of Venus, in a situational snapshot, and the beauty of the evolutionary process, called ‘Birth’!